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HLA Antibody Detection

Bead-based Multiplexing Assay for PRA Screening

LABScreen reagents are powered by Luminex® xMAP® technology, a microbead platform used to deliver multiplex antibody assays in high-PRA patients. This single antigen-bead based assay allows for a precise determination of antibody profiles against HLA, MICA or HNA. The proven reliability of LABScreen’s consistency, high sensitivity and robustness for PRA screening has gained rapid momentum in the transplant community.

Key Features

Proven Accuracy

  • Distinguishes HLA Class I and Class II antibodies
  • Contains a purified single antigen or a defined pool of HLA antigens, including rare alleles
  • Eliminates false positive reactions due to non-HLA antibodies or auto antibodies
  • Single antigen assay identifies negative or safe antigens, even for high PRA patients
  • Detects IgG antibodies

Premier Automation

  • Based on Luminex® xMAP® technology
  • Provides software-driven data acquisition

Maximum Consistency

  • High reproducibility
  • Delivers reaction-to-reaction consistency

LABScreen® Single Antigen

LABScreen® Single Antigen

Donor Specific Antibody Monitoring — A New Standard of Care

LABScreen Single Antigen assays leverage Luminex® bead-based multiplexing technology for monitoring Donor Specific Antibodies (DSA) in high-PRA patients for both pre- and post-transplant applications. This single antigen-bead based assay allows for a precise determination of antibody profiles against HLA, MICA or HNA. The proven reliability of LABScreen’s consistency, high sensitivity and robustness for PRA screening has gained rapid momentum in the transplant community.

In high PRA patients, antibody reactive to one or more dominant epitopes can mask the presence of additional antibody specificities. Conventional clarification methods may not be effective in these cases. LABScreen Single Antigen is designed to screen HLA Class I and Class II antibodies that are reactive to one or more dominant epitopes providing clinicians a comprehensive assay to evaluate antigens found frequently in the population.


Cat No. Product Target Number of Test
LS1A04 LABScreen Single Antigen HLA Class I – Combi HLA-A, HLA-B, HLA-C 25
LS2A01 LABScreen Single Antigen HLA Class II – Group 1 HLA-DRB, HLA-DQB 25